What the Heck Are Polynucleotides?

If the word polynucleotide sounds like something straight out of a biology textbook that’s because it kind of is. But don’t let the scientific name scare you off. In simple terms, polynucleotides are DNA and RNA fragments that help your skin repair itself, boost hydration and improve overall elasticity. They’ve been used in medicine for wound healing for a while, and now they’re making their way into aesthetic treatments.

These injections are all about regeneration. They encourage collagen production, increase blood circulation, and help your skin bounce back from damage—which is why they’re now being explored as a potential solution for cellulite.

Why Does Cellulite Even Exist?

Before we figure out if polynucleotide treatment can help, let’s first understand why cellulite happens. Contrary to popular belief cellulite isn’t just about having extra fat. It’s more about the structure of your skin and what’s happening underneath.

Here’s what’s going on:

• Weak connective tissue—Over time, the bands of connective tissue that hold fat in place lose their strength, letting fat push through and create that uneven, lumpy texture.
• Poor circulation—Less blood flow means fewer nutrients getting to the skin leading to weaker, less elastic tissue.
• Collagen loss—As we age we lose collagen, making skin thinner and more prone to dimpling.
• Hormonal changes—Estrogen levels can influence fat storage and skin thickness, making cellulite more noticeable.
• Genetics—If your mom has cellulite chances are you’ll have it too. Thanks, DNA.

So, what does this have to do with polynucleotides? Well, if these injections can strengthen skin, improve circulation, and help rebuild collagen, they might just make a difference.

Can Polynucleotide Injections Actually Reduce Cellulite?

Early results are promising, but let’s be clear—this isn’t a magic eraser. However polynucleotide treatment does have a few benefits that could help soften the appearance of cellulite:

• Better skin elasticity. Since polynucleotides encourage collagen production, they can help firm up the skin, making cellulite less visible.
• Improved blood circulation. More oxygen and nutrients reaching the skin means healthier, stronger tissue that’s better equipped to resist dimpling.
• Increased hydration. Polynucleotides are known for their ability to retain moisture, plumping up the skin and making it look smoother.
• Stronger connective tissue. If the supportive structure under the skin improves, the fat underneath is less likely to push through and create those dreaded lumps.

What’s It Like to Get Polynucleotide Injections?

If you’re considering trying this treatment, here’s what you can expect:

• It’s not a one-time thing. Most people need about three to five sessions, spaced a few weeks apart to see noticeable results.
• It’s not super painful. The needles are tiny, and while you might feel a little pinch, it’s generally well tolerated.
• There’s little to no downtime. You might have some mild redness or swelling, but nothing major—no hiding in your house for days.

Results take time. Like most treatments that stimulate collagen, improvements happen gradually. You might start noticing changes after a few weeks, with full results appearing in a couple of months.

Does It Actually Work?

The verdict? It seems to help, but it’s not an instant fix. Many patients report firmer, smoother skin after completing their sessions but results can vary depending on factors like age, skin type, and how advanced the cellulite is.

For best results many professionals recommend combining polynucleotide injections with other treatments like microneedling or radiofrequency which also target skin tightening and collagen production. And of course keeping up with regular exercise and a balanced diet can support long-term improvements.

The Bottom Line

If cellulite has been driving you nuts and you’re looking for something beyond the usual creams and scrubs, polynucleotide injections could be worth considering. They help strengthen skin, improve hydration, and boost circulation—all of which play a role in reducing the appearance of cellulite.

That being said, no single treatment is going to completely get rid of cellulite (bummer, I know). The best approach is usually a mix of treatments, plus a little patience. But if you’re looking for a way to support your skin’s health while tackling cellulite? Polynucleotide injections might just be the extra boost you need.

Find out more at Little-Known Facts About Polynucleotides in Mesotherapy | MDA