So What Are Polynucleotides, and Why Should You Care?

Alright, let’s break it down. Polynucleotides might sound like something straight out of a high school biology lesson but they’re actually little powerhouses when it comes to skin health. They’re fragments of DNA and RNA that work behind the scenes to help your skin repair itself, hold onto moisture and stay plump and bouncy.

Unlike that overpriced moisturizer that just sits on top of your skin, polynucleotide injections go deep, helping your cells function better from the inside out. Think of them like a personal trainer for your skin, getting things back in shape so it can retain hydration on its own. They promote cellular repair, boost collagen production and improve circulation—all essential for skin that actually looks and feels hydrated.

How Do Polynucleotide Treatments Help with Hydration?

Your skin’s ability to stay hydrated isn’t just about drinking enough water (though, please hydrate!). It depends on a few key factors:

• The skin barrier: A strong barrier keeps moisture in and junk out. If it’s compromised (thanks to aging, pollution, or over-exfoliating—yes we see you water escapes faster than you can replace it, leaving skin dry and dull.
• Collagen and elastin levels: These proteins are like scaffolding for your skin. When they start breaking down, skin loses its ability to retain moisture, making it look thin, crepey, and—yep—dehydrated.
• Cell turnover: Your skin naturally sheds and regenerates, but when this process slows down, dead cells pile up, blocking fresh, hydrated skin from coming through.

Polynucleotide injections tackle all of these issues at once. They help rebuild the skin barrier, stimulate collagen, and support healthy cell turnover. The result? Skin that’s hydrated from the inside, not just temporarily dewy on the surface.

Are Polynucleotides Just Another Version of Hyaluronic Acid Fillers?

Short answer: Nope! While both can help with hydration they work in completely different ways. Hyaluronic acid fillers act like sponges, instantly pulling water into the skin for that plump smooth effect. Great for quick fixes but once they wear off it’s back to square one.

Polynucleotides on the other hand, don’t just hold moisture—they actually train your skin to retain it better over time. Instead of a temporary plumpness, you get gradual, long-term hydration and overall skin improvement. If hyaluronic acid is like chugging a glass of water when you’re thirsty polynucleotides are like teaching your body how to stay hydrated all day without constant refills.

What’s It Like to Get a Polynucleotide Treatment?

If you’re curious about trying polynucleotide injections, here’s what to expect:

• It’s a process, not an overnight miracle. Most people need three to four sessions, spaced out ovr a few weeks, before they really start seeing results.
• It’s not super painful. The injections are done with fine needles, so while you’ll feel a few pinches, it’s nothing unbearable.
• Minimal downtime. You might have a little redness or swelling, but it usually fades within a day or two. No need to hide out at home.
• Results happen gradually. You won’t wake up with baby-soft skin overnight, but within a few weeks, you’ll start noticing a difference—your skin will feel softer, smoother, and more resilient.

Who Should Try Polynucleotide Treatments?

Pretty much anyone dealing with stubborn dryness, dullness, or aging skin can benefit. But they’re especially great for:

• People with chronically dry skin that doesn’t respond to topical products.
• Those noticing fine lines and loss of skin elasticity caused by dehydration.
• Individuals with weakened skin barriers due to over-exfoliation, sun damage, or environmental stress.
• Anyone looking for a long-term hydration solution instead of quick fixes.

The Bottom Line

If your skincare routine feels like a never-ending cycle of hydration struggles, polynucleotide treatments might be the game-changer you’ve been looking for. Instead of masking dryness with heavy creams, they actually fix the problem at a cellular level—helping your skin retain moisture on its own.

It’s not an instant fix, but the long-term benefits speak for themselves: plumper, healthier, more hydrated skin that stays that way. So if you’re ready to give your skin a real hydration boost, polynucleotides might just be your new best friend.

See for further details by visiting Why Microneedling Could Be the Long-Awaited Skin Treatment for You | MDA